BenchBench-Cloning: Evaluating Molecular Cloning Design and Protocol Development

arXiv cs.AIOctober 27, 2026en

arXiv cs.AI

AI Global Wire

arXiv:2610.33355v1 Announce Type: new Abstract: Molecular cloning is one of the most routine wet-lab workflows, yet existing evaluations of language models in biology mostly test knowledge recall or isolated steps rather than end-to-end experimental planning. We introduce BenchBench-Cloning, a benchmark for large language models comprising 65 molecular cloning tasks grounded in sequence records, laboratory notebooks, and published experimental studies. Planning a molecular cloning experiment requires defining a set of constructs needed for a scientific objective and a construction route to produce them. BenchBench-Cloning contains 50 protocol-development tasks, in which agents produce an exe

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