Distillation, Self-Training, and the Fragility of Learned Chemical Reasoning

arXiv cs.AIOctober 20, 2026en

arXiv:2610.24199v1 Announce Type: new Abstract: Automating synthesis planning for small-molecule drug design requires chemical reasoners that are accurate as well as open to inspection and adaptation, yet frontier language models remain unreliable at predicting reaction outcomes and difficult to deploy, while small open-weight models lack the necessary domain reasoning. We show that frontier supervision can serve as a one-time bootstrap for open models on forward reaction prediction. Our models, Resonance, distill an open-weight teacher's reasoning traces and then learn from their own verified outputs, turning a small base model with near-zero accuracy into a capable reaction predictor, whil

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