Safe to Stop? Risk-Constrained Stopping for Sequential Clinical Diagnosis Agents

arXiv cs.AISeptember 10, 2026en

arXiv:2609.09678v1 Announce Type: new Abstract: Clinical diagnosis agents must decide not only what test to request next, but also when to diagnose or defer. Existing agent benchmarks largely evaluate accuracy after fixed or unconstrained interaction, leaving autonomous stopping reliability implicit. We present Cros, a risk-constrained stopping layer combining state-wise error ranking, policy design on disjoint development splits, and LTT-style exact tests of selective diagnostic error and minimum autonomous coverage for complete sequential policies. Its finite-sample guarantee requires the candidate family, testing rule, and any randomization to be frozen before calibration labels are acces

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