Standalone LLM and a Pre-specified Agentic Pipeline for Explaining ICU Mortality Predictions: a Feasibility Study on the eICU Demo Dataset

arXiv cs.AIAugust 28, 2026en

arXiv:2608.26109v1 Announce Type: new Abstract: Machine-learning models can predict ICU mortality accurately, but feature-attribution methods alone rarely provide the clinical narrative needed for bedside use. Large language models (LLMs) may bridge this gap, and multi-step agentic pipelines are a plausible extension because they separate data interpretation, guideline checking, and final explanation. This revised feasibility study preserves the original standalone-versus-agentic comparison while making the main clinical findings more explicit. Using the retained local eICU Demo artifact set (2,353 ICU stays; 8.1\% mortality), XGBoost achieved an AUROC of 0.855 (95\% CI 0.796--0.906) and an

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